Why Entero Quinol is Still Not Banned In India?

Entero Quinol is antibacterial agent, prescribed for dermatophytosis, mycosis barbae, seborrhoeic dermatitis, infected eczema, furunculosis and pityriasis versicolor (athlete’s foot). But this raises a question the drug is banned in many developed countries so is it safe to take or is doctor has prescribed wrong?

So don’t get confused and this article will end all your questions read this full article to consume an information so that you can take wise decision…
Table of Contents:
1. Introduction
2. The Research on Entero Quinol’s Safety and Risks
3. Conclusion, Safe Dosage and other Precautions
4. Healing the Diarrhoea Without Medication
5. The Reason Behind All of this Research

INTRODUCTION

I am a citizen of India and have written this article to provide the most truthful facts about a controversial tablet, “Entero Quinol” manufactured by East India Pharmaceuticals Works Ltd.

(Note: Even though this website is focussed on the drug “Entero Quinol”, the information provided on all pages is true for all medicines from other brands and generic medicines that have 250mg Quiniodochlor.)

It is a commonly found drug, which can be obtained from most chemists and pharmacies for treating diarrhoea or loose motion.

Note: It is a Schedule H drug and should be sold by retail on the prescription of a Registered Medical Practitioner only yet most of the chemists and pharmacies sell it without any prescription.

Cost as of May 2014:  Rs 16.09 (inclusive of all taxes) for a strip of 20 tablets.
Expiry: 48 months or 4 years.

Entero-Quinol-Tablets-e1400557679254

If you have Googled about Entero Quinol and found a list of banned drugs or have received a message or e-mail which contains a list of banned drugs “around the world” and still in sale in India, it also lists Entero Quinol. Here’s an example excerpted from one such list:

QUINIODOCHLOR:

Anti-diarrhoeal.
Reason for ban : Damage to sight.
Brand name : Enteroquinol.

Such messages have spread like wildfire and even more after the famous actor Aamir Khan’s show, Satyamev Jayate, targeted the corrupt practices of doctors and pharmaceutical companies in India.

THE RESEARCH ON ENTERO QUINOL’S SAFETY AND RISKS

After a lot of research and going through a lot of websites, I finally found out the reason for this ban in a book, to be precise,  page 452 of Essentials of Pharmacology for Dentistry by K. D. Tripathi. You can preview the page on Google Books, here’s the link and below it is a screenshot of it’s text (with the important paragraphs marked with red coloured borders):

http://books.google.co.in/books?id=1Iwa2-JIgkQC&pg=PA452&lpg=PA452&dq=quiniodochlor&source=bl&ots=f6L0w6hUW-&sig=L1n-FEuVVN7MtEs0SZ2SlR4W__I&hl=en&sa=X&ei=z4d3U_KaOpeVuATJhIHQAw&redir_esc=y#v=onepage&q=quiniodochlor&f=false

Enteroquinol Side Effects
Enteroquinol Side Effects

After finding this information that I have mentioned above, I researched more on the 1960s and 1970s Japanese situation and here’s what I found on the Wikipedia pagehttp://en.wikipedia.org/wiki/Clioquinol, about the epidemic in Japan:

Clioquinol’s use as an antiprotozoal drug has been restricted or discontinued in some countries due to an event in Japan where over 10,000 people developed SMON(subacute myelo-optic neuropathy) between 1957 and 1970. The drug was used widely in many countries before and after the SMON event without similar reports. As yet, no explanation exists as to why it produced this reaction, and some researchers have questioned whether clioquinol was the causative agent in the disease, noting that the drug had been used for 20 years prior to the epidemic without incident, and that the SMON cases began to reduce in number prior to the discontinuation of the drug. Theories suggested have included improper dosing, the permitted use of the drug for extended periods of time, and dosing which did not consider the smaller average stature of Japanese; however a dose dependant relationship between SMON development and clioquinol use was never found, suggesting the interaction of another compound. Researchers have also suggested the SMON epidemic could have been due to a viral infection with an Inoue-Melnick virus.

Thus we can conclude that there isn’t any proven conclusion that the contents of Entero Quinol were responsible for the SMON(subacute myelo-optic neuropathy) of the 10s of thousands of Japanese people in the 1960s.

On further research, I found a website which helped me more as it tells us the proper dosage and the harmful dosage:

http://www.drug2day.com/index.php/drug/display/6140

An excerpt from the above link:

SAFETY PROFILE :The use of these drug, especially at doses exceeding 2gm per day for long periods, is unfortunately associated with significant risk. Due to the un-certainty about the development of subacute myeloopticneuropathy (SMON) the use of these agents is always warranted for the treatment of intestinal amoebiasis.

It is clearly mentioned above that one needs to consume 2gm i.e. 2,000mg of Entero Quinol for many days for the severe side effects. The tablet is of just 250 mg and is advised to be taken twice or thrice for 2-3 days, thus, it isn’t banned in India as it is prescribed in safe doses!

CONCLUSION, SAFE DOSAGE AND OTHER PRECAUTIONS

I concluded from all of this research that it is safe to consume 4 to 6 tablets of Entero Quinol daily for 2 to 5 days for adults.

After this research, I obtained a strip of Entero Quinol (a three year old strip lying in the medicine bag) and found a few interesting things written on it which could have helped me know before hand (and save me from more than an hour of research) that it’s main risk was optic nerve damage!

Here’s a close-up shot of the warning written on the strip:

Warning on Entero Quinol Tablet Strip about Optic Nerve Damage: "Relatively prolonged and uninterrupted treatment with halogenated hydroxyquinoline derivatives used in high dosage for more than 14 days has been reported to cause peripheral neuritis and damage to optic nerves in isolated cases."
Warning on Entero Quinol Tablet Strip about Optic Nerve Damage:
“Relatively prolonged and uninterrupted treatment with halogenated hydroxyquinoline derivatives used in high dosage for more than 14 days has been reported to cause peripheral neuritis and damage to optic nerves in isolated cases.”

“Relatively prolonged and uninterrupted treatment with halogenated hydroxyquinoline derivatives used in high dosage for more than 14 days has been reported to cause peripheral neuritis and damage to optic nerves in isolated cases” reads the warning.

The safe dosage of Entero Quinol (as mentioned on the tablet strip and on medical websites) is 500 mg (2 tablets of 250 mg) thrice daily or as directed by the physicians.

NOTE: I found during my research that doctors have recommended not to consume Entero Quinol during pregnancy, if you are pregnant or you feel you may be pregnant then contact your doctor for a safe alternative.
And I also found in the book link given above that it is banned for pediatric use in India so consult your doctor when treating children.

After using Entero Quinol for a few days, if the diarrhoea doesn’t stop, you should immediately get a stool test and a few blood tests (advised by your doctor) done. This will result in a proper diagnosis.

HEALING THE DIARRHOEA WITHOUT MEDICATION

Many people who believe in the power of self healing or want to use safer home remedies rather than medication like Entero Quinol which always carries some risks, here’s a great website that I found to be the best for treating your diarrhoea yourself, and also for obtaining knowledge more knowledge about it, do read it till then end:

http://www.stewartnutrition.co.uk/nutritional_emergencies/prolonged_diarrhoea_in_adults.html

The Reason Behind All of This Research

I am a strong believer in the power of self healing by positive thoughts. It has been more than two years since I took any antibiotics, I have healed sore throats, throat infections and fevers using only my brain and thoughts.

One day, in the first week of May 2014, I consumed Pao Bhaaji and Gol Gappe (Paani Puri) at a relative’s home in Mathura, India. Most of the ingredients were made at home but the Paav of Paav Bhaaji and Puri of Gol Gappe were bought from the local market. Which I now believe were made and kept in very unhygienic conditions at the shop. Diarrhoea started right from the next day of consuming them and went on for 2-3 weeks and I am still in the process of healing and recovering while I write this article!

I had understood by now that there was some bug in the food which now resided in my tummy and the body was reacting by flushing out whatever I ate. This was a self-diagnosis after all the research on trusted medical websites, which I don’t recommend to everyone!

I had found out that as medicines like Entero Quinol are banned in developed countries, many people let their bodies heal by themselves by sticking to a strict diet of foods like Banana, Rice, Curd, Apple (preferably stewed) and Toast.

I also started following it, and didn’t wanna consume Entero Quinol as at that time I only knew that it is banned in developed countries and neither the reason why it banned there and nor the reason why it isn’t banned in India!

Source: Enteroquinol.com

(Special Thanks)

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